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Translational insights into statin-induced myotoxicity: Differential impact of lipophilic and hydrophilic statins on iPSC-derived skeletal muscle cells from patients with familial hypercholesterolemia

Year: 2025
Type: article
Source: Toxicology
DOI: 10.1016/j.tox.2025.154159
Authors: Raul Hernandes Bortolin, Felipe de Souza Leite, Andre Ducati Luchessi, Joyce Esposito, Igor Neves Barbosa, Renata Caroline Costa de Freitas, Abhijeet Rajendra Sonawane, Sasha Anna Singh, Elena Aikawa, Kayque Alves Telles-Silva, Thiago Dominguez Crespo Hirata, Antonia Pereira Rosa Neta, Ernesto Goulart, Luiz Carlos Caires-Júnior, Thais Maria da Mata Martins, Patrícia Semedo, Danielle de Paula Moreira, Michel Naslavsky, Andre Arpad Faludi, Rodrigo Marques Gonçalves, Daniel Branco Araujo, Vanessa Barbosa Malaquias, Glaucio Monteiro Ferreira, Carlos DeOcesano-Pereira, Ana Marisa Chudzinski-Tavassi, William T. Pu, Mayana Zatz, Rosario Dominguez Crespo Hirata, Mario Hiroyuki Hirata
Institutions: Boston Children's Hospital, Harvard University, Universidade de São Paulo, Universidade Federal do Rio Grande do Norte, Brigham and Women's Hospital, Instituto Dante Pazzanese de Cardiologia, Instituto Butantan
Language: English
Subfield: Surgery
Field: Medicine
Open Access status: closed
Funders: American Heart Association, Fundação de Amparo à Pesquisa do Estado de São Paulo, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico, National Institutes of Health, National Heart, Lung, and Blood Institute
Awards: CEGH-CEL - Human Genome and Stem Cell Research Center, G29316538, G4409789018, Macrophage-derived microcalcificaitons, New driver of fibrosis and calcification in CAVD, Genomics, epigenomics and pharmacogenomics characterization of familial hypercholesterolemia in the Brazilian population, Improving Mitral Compensation In Ischemic Regurgitation, G7043344092, G8044010125
OpenAlex ID: W4409572236
FWCI: 2.797
Cites: 76
Cited by: 3
Related to: 10