Work

Oxidation of low-density lipoprotein by hemoglobin causes pulmonary microvascular endothelial barrier dysfunction through lectin-like oxidized LDL receptor 1

Year: 2025

Type: article

Abstract: This study demonstrates that oxidation of low-density lipoproteins (LDLs) by hemoglobin or heme disrupts the pulmonary microvascular endothelial barrier; the scavenger receptor lectin-like oxidized LDL receptor 1 mediates this response. This study reveals a novel mechanism by which the pulmonary microvascular endothelium could be targeted for therapeutic intervention during hemolytic or inflammatory pathologies.

Source: American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI: 10.1152/ajplung.00026.2025

Authors: Jamie E. Meegan, Kyle J. Riedmann, Samantha Gonski, Joel S. Douglas, Avery M. Bogart, Lorraine B. Ware, Julie A. Bastarache

Institutions: University of South Alabama, Vanderbilt University Medical Center, Vanderbilt University

Language: English

Topic: Atherosclerosis and Cardiovascular Diseases

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Francis Family Foundation, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences

Awards: G1620059457, G2960585124, Medical Scientist Training Program, G4315922379, G4451849601, G4548540823, G4620506257, G4969333640, G5556132178, G5680278680, G5949053937, G7578948435, G8554837931, Cell-free hemoglobin-oxidized LDL-LOX-1 axis and microvascular hyperpermeability during sepsis, G933073435

OpenAlex ID: W4409576404

FWCI: 0.886

Cites: 39

Cited by: 3

Related to: 10