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Sex-specific systemic metabolic predictors of resistance to calorie restriction-induced weight loss in obese diversity outbred mice

Year: 2025
Type: article
Abstract: Using a population of obese diversity outbred (DO) mice, we interrogated plasma predictors of resistance to calorie restriction-induced weight loss in nonresponders versus responders to the diet intervention. Lower leptin levels significantly predicted resistance in both sexes. Sexually dimorphic predictors included lower levels of glucose in males and insulin, resistin, and plasminogen activator inhibitor-1 (PAI-1) in females. Hence, genetically and phenotypically heterogeneous diversity outbred mice may be useful for identifying metabolic predictors for personalizing weight loss interventions.
DOI: 10.1152/ajpregu.00220.2024
Authors: Evan M. Paules, Melissa VerHague, Anju A. Lulla, Katie A. Meyer, Michael F. Coleman, Jody Albright, Brian J. Bennett, Kari E. North, Annie Green Howard, Penny Gordon-Larsen, Isis Trujillo-Gonzalez, John E. French, Stephen D. Hursting
Language: English
Open Access status: green
Awards: G2251325701, G3783191424, G4855478099, G622761962, G692827476, G758060882, Nutrition Obesity Research Center (NORC)
OpenAlex ID: W4409577470
FWCI: 1.056
Cites: 58
Cited by: 3
Related to: 10