Work

Drug repurposing reveals posaconazole as a CYP11A1 inhibitor enhancing anti-tumor immunity

Year: 2025

Type: article

Abstract: Publisher of over 50 scientific journals across the life, physical, earth, and health sciences, both independently and in partnership with scientific societies including Cell, Neuron, Immunity, Current Biology, AJHG, and the Trends Journals.

Source: iScience

DOI: 10.1016/j.isci.2025.112488

Authors: Jhuma Pramanik, Sanu Korumadathil Shaji, Megan Zaman, Bethany Brown, Baojie Zhang, Yumi Yamashita-Kanemaru, Natalie Z.M. Homer, Hosni A.M. Hussein, Qiuchen Zhao, Klaus Okkenhaug, Rahul Roychoudhuri, Abhik Mukhopadhyay, Bidesh Mahata

Institutions: University of Cambridge, The Queen's Medical Research Institute, University of Edinburgh, Cambridge Crystallographic Data Centre

Language: English

Topic: Computational Drug Discovery Methods

Subfield: Computational Theory and Mathematics

Field: Computer Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: National Science Foundation, UK Research and Innovation, Cancer Research UK, Medical Research Council, Biotechnology and Biological Sciences Research Council

Awards: G1586776820, G3894098922, G5128237474, Steroid-producing immune cells promote metastatic dissemination of cancer cells, G6959720611, 19-BBSRC-NSF/BIO: Inference of isoform-level regulatory infrastructures with studies in steroid-producing cell

OpenAlex ID: W4409577650

FWCI: 2.393

Cites: 38

Cited by: 5

Related to: 10