Work

Sex-specific dysregulation of cardiac-enriched microRNAs with age in Drosophila melanogaster

Year: 2025

Type: article

Abstract: Advancements in healthcare and diet have increased life expectancy, doubling the population aged 60 and above by 2050. However, this longevity raises the risk of chronic diseases, especially cardiovascular diseases. We examined age-related changes in cardiovascular-enriched microRNAs in the Drosophila melanogaster heart. This first-of-its-kind observational study tracks microRNA changes across life stages. It highlights sex-specific expression of miRNAs, providing crucial insights into cardiac aging. It lays a strong foundation for future research on microRNA in heart health.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00134.2025

Authors: Lijo N. Varghese, Philip W. Sheard, Daryl O. Schwenke, Rajesh Katare

Institution: University of Otago

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: University of Otago