Work

Splenic modulation of the early inflammatory response to regional and global ischemia/reperfusion injury in swine

Year: 2025

Type: article

Abstract: Acute reperfused myocardial infarction (AMI) and sudden cardiac arrest (SCA) are characterized by ischemia-reperfusion injury (IRI) and inflammation. Although prior studies implicated the spleen as a primary source of inflammatory leukocytes after regional IRI in rodents, our findings indicate that, in swine, the spleen is not required for leukocyte mobilization after AMI or SCA. However, splenic erythrocyte mobilization during whole body IRI increases arterial oxygen content during CPR and may influence outcomes after SCA.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00714.2024

Authors: Tyler J. Rolland, Emily R. Hudson, Luke A. Graser, Sumbule Zahra, Daniel Cucinotta, Brian R. Weil

Institutions: VA Western New York Healthcare System, University at Buffalo, State University of New York

Language: English

Topic: Cardiac Ischemia and Reperfusion

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: American Heart Association, National Institutes of Health, National Heart, Lung, and Blood Institute, National Center for Advancing Translational Sciences