Work

Thiamine hydrochloride aided mechanochemical reaction: An efficient synthesis of Aryl-1,2,3-triazoles in copper ball milling conditions

Year: 2025

Type: article

Abstract: The current study investigates the catalytic efficacy of the natural organo-catalyst Vitamin B 1 (Thiamine Hydrochloride i.e. VB 1 ) in the synthesis of Aryl-NH-1,2,3-Triazoles utilizing Cu ball milling conditions. The reaction involving β-nitrostyrenes, trimethylsilylazide (TMSN 3 ), and potassium carbonate, facilitated by the VB 1 catalyst in Cu ball milling condition, has been successfully reported for the first time to yield the corresponding 4-Aryl-NH-1,2,3-Triazoles through a green chemistry approach. The methodology outlined in this study follows the concepts of green chemistry in its technique, incorporating elements such as a biodegradable catalyst, optimized ball milling conditions, reduced reaction times, high product yields, and the recyclability of both the catalyst and copper balls, all while eliminating the need for additional metal catalysts and ensuring high atom economy.

Source: Sustainable Chemistry for the Environment

DOI: 10.1016/j.scenv.2025.100250

Authors: Pankaj V. Ledade, Jitendra K. Gunjate, Twinkle S. Wankhede, Sami H. Mahmood, Trimurti L. Lambat

Institutions: Shri Shivaji Education Society, Amravati's Science College, Nagpur, University of Jordan, Michigan State University

Language: English

Topic: Click Chemistry and Applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: gold

Estimated APC paid: $1,440