Work

Pharmacokinetics of Matrine in blood and prostate tissue: a microdialysis-HPLC study in a rabbit model

Year: 2025

Type: article

Abstract: KangFuXiaoYan suppository exhibits therapeutic potential for chronic prostatitis (CP) ,however, its in vivo pharmacokinetic process remains to be elucidated. This study investigated the pharmacokinetics of Matrine , the primary bioactive component of KangFuXiaoYan suppository, using high-performance liquid chromatography (HPLC) with microdialysis in rabbits. The results showed that the C max of Matrine in jugular vein and prostate tissue were (86.92 ± 2.66) and (45.33 ± 3.65) mg L -1 ,the T max were (30 ± 0.00) and (45 ± 0.00) min, the T 1/2 were (23.55 ± 1.76) and (26.50 ± 5.57) min, the AUC 0-t were (4192.77 ± 67.85) and (2919.78 ± 40.17) mg min L -1 ,the MRT 0-t were (48.90 ± 0.13)and (56.25 ± 1 .06) min. Matrine absorption, distribution, and penetration into prostate tissue were quantified. The results demonstrated rapid absorption into blood and prostate tissue, achieving a penetration rate of 73 %, suggesting potential therapeutic effectiveness for chronic prostatitis treatment. These findings provided experimental support for the clinical application of rectally administered KangFuXiaoYan suppository.

Source: Phytomedicine Plus

DOI: 10.1016/j.phyplu.2025.100801

Authors: Yu Liu, Gefei He, Jianye Yan, Meimin Pan, Binqing Qu

Institutions: Hunan University of Traditional Chinese Medicine, The First Hospital of Changsha

Language: English

Topic: Traditional Chinese Medicine Analysis

Subfield: Complementary and alternative medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,590