Work

Optimizing Heart-Kidney Interaction for Cancer Detection Through Physiological Process Simulation as a Decision Support System

Year: 2025

Type: article

Abstract: Decision support system (DSS) is a computer-based tool used to improve decision-making capabilities for any organization, using analysis of the available data.The heart-kidney (HK) model proposed in this paper as a DSS simulates the physiological processes of the heart and kidneys in the human body to support cancer detection. The first part of the HK algorithm is inspired by the functions of the heart, where blood molecules (solutions) are sent to the heart, simulating the processes of oxygenation and the pumping of oxygenated blood to the kidneys as a local search. The solutions generated by the heart are then fed into the kidney-inspired algorithm (KA), which performs filtration, reabsorption, secretion, and excretion. The heart component enhances the KA's local search capability, guiding the algorithm toward optimal solutions. The HK model is evaluated on eight test functions, with results compared to those of the heart algorithm and KA alone. Additionally, the HK algorithm's effectiveness as a decision support system is tested on benchmark classification and time series prediction problems, with statistical analysis against existing methods in the literature. Finally, the HK algorithm is applied to cancer detection from microRNA data, demonstrating its potential in optimizing decision-making processes in healthcare.

Source: IEEE Access

DOI: 10.1109/access.2025.3562341