Anti-inflammatory activity of Avicennia germinans ’ adventitious roots and first description of their metabolites
Year: 2025
Type: article
Abstract: This study investigated the anti-inflammatory and antioxidant activity of adventitious roots (AR) of Guyanese mangrove Avicennia germinans, used in folk traditional medicine (FTM). Using bio-guided fractionation, we searched for extracts with activities that can be used for therapeutic purposes. Our findings revealed an interesting anti-inflammatory activity of CH2Cl2 and EtOAc fractions from which eight compounds were isolated and identified by NMR: two naphtoquinone derivatives: avicennone C (1) and dehydro-α-lapachone (2), two triterpenes: β-betulinic acid (3) and betulinaldehyde (4), two phenylethanoid glycosides: trans-verbascoside (6) and isoverbascoside (8), one iridoid: geniposidic acid (5) and one naphtoquinone: rubinaphtin A (7). These compounds are described for the first time in the AR of A. germinans. Among them, 3 was the most active and abundant, suggesting that it mainly contributed to the fractions’ activity. This work reports the anti-inflammatory potential of A. germinans AR extracts for the first time and supports its use in FTM.
Source: Natural Product Research
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4409586207