Work

Nickel‐Catalyzed Hydrogenation of Enamides and Quinolines via Photoinduced Hydrogen Atom Transfer

Year: 2025

Type: article

Abstract: Comprehensive Summary Radical hydrogenation facilitated by metal (Fe, Co, Mn, etc.) hydride‐mediated hydrogen atom transfer (mHAT) has emerged as a powerful technique in organic synthesis. However, nickel‐hydride (NiH) catalyzed radical hydrogenation has remained largely unexplored. Herein, we develop a NiH catalytic system that achieves the hydrogenation of enamides in high efficiency. This strategy stands out for its ability to hydrogenate challenging quinolines at room temperature, avoiding the catalyst poisoning and deactivation by quinolines and their hydrogenation products. Furthermore, the deuteration of alkenes was achieved with high deuteration rates (up to > 99%), underscoring its potential in the synthesis of deuterium‐containing molecules.

Source: Chinese Journal of Chemistry

DOI: 10.1002/cjoc.70039

Authors: Zi‐Kui Liu, Lan Qin, Yi Wei, Xiao‐Qiang Hu, You‐Quan Zou

Institutions: South Central Minzu University, Wuhan University, Zhongnan Hospital of Wuhan University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: National Natural Science Foundation of China, Wuhan University

Awards: G3273209108, G3641153866, G5970720184, G6054136423