Year: 2025
Type: article
Study design: Observational Study
Abstract: infection. We decided to explore the influence of genetic factors related to both innate and adaptive immunity in acute Q fever susceptibility. TLR2 (Arg753Gln) and TLR4 (Asp299Gly, Thr399Ile) polymorphisms, along with HLA-DRB1 alleles, were analyzed for 38 patients with acute Q fever, 38 matched controls, and 121 blood donors. No significant associations were found for TLR polymorphisms. However, HLA-DRB1*04 was more frequent in patients. HLA-DRB1 variants may play a role in Q fever susceptibility, supporting the need for further investigation into their potential implications for vaccination and risk assessment.
Source: Pathogens
Authors: José-María Robaina Bordón, José-Luis Pérez-Arellano, Olga Montes-Ares, Alberto Torio-Ruiz, Michele Hernández-Cabrera, Elena Pisos-Álamo, Cristina Carranza-Rodríguez
Language: English
Subfield: Parasitology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,654
OpenAlex ID: W4409588067