Work

Highlights of 2024: The multifaceted roles of ILC3s in mucosal immunity and inflammation

Year: 2025

Type: article

Abstract: In this article for the Highlights of 2024 Series, we discuss research on Group 3 innate lymphoid cells (ILC3s), which revealed their complex roles in mucosal immunity and inflammation. ILC3s can migrate from the gut to the kidneys, contributing to renal fibrosis. Their functions are metabolically regulated, with proteins such as nucleophosmin 1 and Tox2 influencing oxidative phosphorylation and glycolysis, respectively. ILC3s also express immune checkpoint molecules (e.g. cytotoxic T-lymphocyte antigen 4 and programmed cell death1), which modulate inflammation. These findings highlight the tissue-specific roles of ILC3s and the need for targeted immunotherapies.

Source: Immunology and Cell Biology

DOI: 10.1111/imcb.70021

Authors: Xin Shen, Xianzhi Gao, Lie Wang

Institutions: Zhejiang University, First Affiliated Hospital Zhejiang University

Language: English

Topic: IL-33, ST2, and ILC Pathways

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Natural Science Foundation of China, National Key Research and Development Program of China, Fundamental Research Funds for the Central Universities