Year: 2025
Type: article
Study design: Observational Study
Abstract: BackgroundDisordered metabolism affects risk for cognitive decline, Alzheimer's disease, and other dementias, likely through pathways involving adipokines.ObjectiveAnalyze incident cognitive impairment in relation to leptin, adiponectin, body mass index, and other risk factors.MethodsNested case-control study within the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort of 30,239 adults in the US. Cases with incident cognitive impairment (n = 489) scored >1.57 SD below demographically adjusted means on ≥2 of 3 cognitive tests: word list learning, word list delayed recall, and category fluency. Cognitively intact controls (n = 583) were randomly selected within demographic strata. Leptin and adiponectin were assayed in thawed blood that had been stored at baseline.ResultsIn participants with normal weight, lower leptin was associated with higher odds of cognitive impairment. Relative to leptin = 25 ng/mL, adjusted ORs were 1.5 (95% CI: 1.2, 1.9) at leptin = 15 ng/mL, 0.8 (0.8, 0.9) at leptin = 30 ng/mL, and 0.5 (0.4, 0.8) at leptin = 45 ng/mL. In participants with obesity, higher adiponectin was associated with higher odds of cognitive impairment. Relative to adiponectin = 25 ng/mL, adjusted ORs were 0.8 (95% CI: 0.7, 1.0) at adiponectin = 15 ng/mL, 1.1 (1.0, 1.2) at adiponectin = 30 ng/mL, and 1.3 (1.0, 1.7) at adiponectin = 45 ng/mL. Associations of adipokines with cognitive impairment varied across levels of other risk factors.ConclusionsAdipokines, in concert with body mass index, play complex roles in cognitive health, with many avenues open for further investigation.
Source: Journal of Alzheimer s Disease
Authors: Evan L Thacker, Reena Karki, Rachel Gabor, Natalie J Blades, Russell P Sawyer, Cyrille N Kouambo Beckodro, Quinn Preece, Samuel Prince, McKay M Smith, Sarah R Gillett, Suzanne E Judd, Richard E Kennedy, Jorge R Kizer, Deborah A Levine, William M McClellan, Manjula Kurella Tamura, Frederick W Unverzagt, Virginia G Wadley, Mary Cushman
Institutions: Brigham Young University, University of Cincinnati, University of Vermont, University of Alabama at Birmingham, San Francisco VA Medical Center, University of California, San Francisco, San Francisco VA Health Care System, University of Michigan, Michigan Medicine, Emory University, VA Palo Alto Health Care System, Stanford Medicine, Stanford University, Indiana University School of Medicine
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4409591249