Investigation of interleukines-4, 6 and malondialdehyde levels in serum of Iraqi patients with chronic kidney diseases
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background Immune dysfunction develops early in the course of renal failure in patients with chronic kidney disease and occurs independently of the underlying disease. Cytokines play an essential role in the control and regulation of the immune and inflammatory systems. Objective The current study aims to estimate Interleukin 4, Interleukin 6, and Malondialdehyde in the blood of Iraqi patients with chronic kidney disease. Methods In this study, 50 Iraqi chronic kidney disease patients (males 17 and females33) and 50 apparently healthy as the control group (male27 and females23) aged (20–65)years who attended lmamain Al-Kadhemain Medical Teaching Hospital and Al-Numan Hospital in Baghdad, Iraq. Interleukin 4, Interleukin 6, and malondialdehyde were measured using an enzyme-linked immunosorbent assay technique. Results The serum level of IL-4 and IL-6 showed highly significant differences between chronic kidney disease patients and healthy control groups m as the mean value of both interleukin levels in patient groups was (25.524 ± 16.295, 12.844 ± 4.863) respectively, and mean of the control group (13.562 ± 7.488, 5.533 ± 2.970) respectively. The mean of malondialdehyde was (25.160 ± 17.152 and18.470 ± 6.545) in chronic kidney disease patients and control groups, respectively. There was a highly significant positive correlation between Interleukin6 and malondialdehyde (r = 0.862, P = 0.0001, r = 0.598, P = 0.0001), respectively. In addition, there was a highly significant positive correlation between Interleukin4 and malondialdehyde (r = 0.862, P = 0.0001, r = 0.662, P = 0.0001) respectively. There was a highly significant positive correlation between Interleukin 4 and Interleukin 6 (r = 0.598, P = 0.0001) and (r = 0.662, P = 0.0001) respectively. Conclusions The increased levels of Interleukin 4, Interleukin 6, and malondialdehyde are an indication of the progression in Iraqi patients with chronic kidney disease.
Source: Human Antibodies
Authors: Marwa AL-Razak, Basima AlSaadi, Ali Al Saedi
Institutions: University of Baghdad, Baghdad Medical City
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funder: University of Baghdad
OpenAlex ID: W4409591846