Work

Preparation and use of SER/GLU-based DES as a novel and potent catalyst for the green synthesis of pyrazolopyranopyrimidines

Year: 2025

Type: article

Abstract: Based on the eutectic point phase diagram, a novel natural deep eutectic solvent (SER/GLU-DES) was prepared by a mixture of one mole of serine (SER) and one mole of glutaric acid (GLU), and characterized by various techniques. Then, it was used as a novel and potent catalyst for the synthesis of two sets of biologically important pyrazolopyranopyrimidines via a one-pot four-component condensation reaction of ethyl acetoacetate, hydrazinehydrate/ phenylhydrazine, barbituric acid and aldehydes at 70 °C, in solvent-free conditions.

Source: Scientific Reports

DOI: 10.1038/s41598-025-97469-3

Authors: Nastaran Dehnokhalaji, Davood Habibi, Arezo Monem, Afagh Ranjbaran

Institution: Bu-Ali Sina University

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,690

Funder: Bu-Ali Sina University