Work

Hyperandrogen-induced imbalance of FOXO4-AR regulatory loop contributes to ovulatory disorders in polycystic ovary syndrome

Year: 2025

Type: article

Abstract: . AR-mediated androgen action is known to play a key role in the development of PCOS. Notably, AR repressed FOXO4 expression by binding to its promoter, whereas FOXO4 inhibited AR protein levels through protease degradation, thus establishing a regulatory loop between AR and FOXO4 that was disrupted by hyperandrogenism. This study demonstrates that hyperandrogenism inhibits LH surge formation and disrupts the regulatory balance between FOXO4 and AR, which may contribute to the continued exacerbation of PCOS.

Source: Molecular Therapy — Nucleic Acids

DOI: 10.1016/j.omtn.2025.102543