Work

Changes in the thalamocortical component of high frequency oscillations following botulinum toxin treatment in cervical dystonia

Year: 2025

Type: article

Abstract: • The study provides neurophysiological evidence of changes in HFOs HFOs thalamocortical component after Botulinum toxin (BoNT) in cervical dystonia. • A significant increase in early HFOs was observed in cervical dystonia following BoNT, suggesting improved thalamocortical communication. • The use of HFOs and SAI offers a cost-effective and accessible method to evaluate the central effects of Botulinum toxin. This study aims to investigate the central effects of Botulinum toxin type A (BoNT-A) on the somatosensory system in patients with cervical dystonia (CD), focusing on the thalamocortical pathway using high-frequency oscillations (HFOs) and short-latency afferent inhibition (SAI). An observational longitudinal study was conducted on 10CD patients and 10 healthy controls (HC). HFOs and SAI were assessed for CD and HC at baseline (T0; the day before BoNT-A treatment). Then only for CD patients, SAI and HFOs were assessed again 30 days after (T1) BoNT-A treatment. Changes in SAI values and HFO early and late area between T0 and T1 in CD patients were evaluated with the Wilcoxon signed-rank test. At T0, CD patients exhibited significantly reduced early HFOs compared to HC, with no significant differences in late HFOs or SAI values. After BoNT-A treatment, a significant increase in early HFOs was observed in CD patients at T1, while late HFOs and SAI values remained unchanged. The findings suggest that BoNT-A treatment may have central effects on thalamocortical activity, as evidenced by changes of early HFOs in CD patients following injections. This study provides neurophysiological evidence supporting the central effects of BoNT-A on the somatosensory system and corroborates the idea of a somatosensory involvement in CD pathogenesis. This funding could pave the way for future integrated treatment approaches.

Source: Clinical Neurophysiology

DOI: 10.1016/j.clinph.2025.03.048