Year: 2025
Type: article
Abstract: This article analyzes the molecular-genetic mechanisms underlying the development of salivary gland tumors. Key genetic mutations (PLAG1, HMGA2, CTNNB1) and their impact on tumor growth are examined. The role of dysregulated signaling pathways (Wnt/β-catenin, PI3K/AKT/mTOR, NF-kB) in carcinogenesis is highlighted. Particular attention is given to the expression of molecular markers (CK7, p40, p63, SOX10, S-100) and their diagnostic significance. The influence of chronic inflammation and pro-inflammatory cytokines (IL-6, TNF-α) on tumor progression is discussed. This review underscores the need for further research to develop new diagnostic and therapeutic strategies aimed at identifying molecular targets and improving approaches to the treatment of salivary gland tumors.
Source: Medical science of Uzbekistan
Authors: Jasur Rizaev, Alisher Akhrorov
Institution: Samarkand State Medical Institute
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4409605621