Work

Metal-Free Catalytic Synthesis of Tetrasubstituted Furans from α-Hydroxy Ketones and Cyano Compounds

Year: 2025

Type: article

Abstract: A novel method for the efficient and straightforward synthesis of tetrasubstituted furans is presented, employing a base-catalyzed reaction of α-hydroxy ketones and cyano compounds. The reaction proceeds under relatively mild conditions, utilizes readily available starting materials, and exhibits good functional group tolerance and high yields. Notably, this reaction obviates the need for expensive metal catalysts and introduces crucial functional groups such as amino and cyano moieties. Furthermore, it avoids the prerequisite functionalization of substrates, thereby enhancing atomic economy.

Source: Molecules

DOI: 10.3390/molecules30081832

Authors: Yu Zeng, Shi-Hang Yang, Ji-Lin Guo, Yun Li, Ting Lin, Zhao-Yang Wang

Institution: South China Normal University

Language: English

Topic: Organic Chemistry Synthesis Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $3,258

Funders: National Natural Science Foundation of China, Basic and Applied Basic Research Foundation of Guangdong Province