Year: 2025
Type: article
Abstract: Oleracrylimide E, a new alkaloid from Portulaca oleracea L., shows significant bioactivity. Then, the pharmacokinetics of this alkaloid after its intravenous administration at dose of 2.0 mg/kg body weight in rat plasma was evaluated using UHPLC with vitexin-2″-O-rhamnoside as an internal standard (IS). The UHPLC-ESI-Q-TOF/MS method was applied to investigate the metabolism of Oleracrylimide E in rats in response to the immediate conversion of Oleracrylimide E into other metabolites after its oral administration. As a result, a total of 16 metabolites of Oleracrylimide E were identified in the plasma, urine, and fecal of the experimental rats.
Source: Biomedical Chromatography
DOI: 10.1002/bmc.70067
Authors: Zheming Ying, Kaiyun Jiang, Chengyu Wang, Hongzhe Zhang, Junjie Yao, Yingdai Zhao, Xixiang Ying, Yanling Ren
Institution: Liaoning University of Traditional Chinese Medicine
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Award: G171127883
OpenAlex ID: W4409608900