Work

Podocyte Glucocorticoid Receptor Expression and Treatment Outcome in Idiopathic Nephrotic Syndrome

Year: 2025

Type: article

Abstract: Minimal change disease and focal segmental glomerulosclerosis are histologic manifestations of idiopathic nephrotic syndrome (iNS), which is considered a primary podocytopathy.1 Complete proteinuria remission is the aim of iNS treatment and is associated with long-term preserved kidney function. Partial remission is also associated with improved outcome; however, there remains a significant risk of relapses and progression.2 Most patients with iNS receive high-dose glucocorticoid (GC) treatment; however, the proteinuria response is highly variable and unpredictable in an individual patient.

Source: Kidney International Reports

DOI: 10.1016/j.ekir.2025.04.034

Authors: Bartholomeus T. van den Berge, Jitske Jansen, Jack F.M. Wetzels, Bart Smeets, Rutger J. Maas

Institutions: Radboud University Medical Center, Radboud University Nijmegen, Universitätsklinikum Aachen

Language: English

Topic: Renal Diseases and Glomerulopathies

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,800