Work

A case of recurrent Candida glabrata fungemia and successful treatment with rezafungin

Year: 2025

Type: article

Abstract: Antifungal resistance in Candida glabrata can develop to different classes of drugs, including the azoles and echinocandins. This organism is known to cause infective endocarditis with a particular predilection for prosthetic valves. Herein we present a case of recurrent fungemia with C. glabrata in a middle-aged woman with Tetralogy of Fallot who had a right ventricle to pulmonary artery conduit, and a transcatheter pulmonary valve replacement in the past. Her isolate showed increasing minimum inhibitory concentrations (MIC) to various antifungals with higher MICs to azoles, including resistance to fluconazole, resulting in limited treatment options. She had affliction of her prosthetic pulmonic valve with C. glabrata and was treated with the second-generation echinocandin, rezafungin, for six months. This case illustrates the tolerability profile of long-term treatment with rezafungin.

Source: IDCases

DOI: 10.1016/j.idcr.2025.e02233

Authors: Divya Chandramohan, Samantha Aguilar, Gerard Gawrys, Nathan P. Wiederhold, Kristi Traugott, Thomas F. Patterson

Institution: The University of Texas at San Antonio Health Science Center

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,370