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Spindle cell carcinoma of the lung with myogenic differentiation in a young female patient: a rare case report

Year: 2025

Type: article

Abstract: Background: Spindle cell carcinoma is a sporadic sarcomatoid neoplasm in the lung and pleura, comprising only 0.3-1.3% of all malignant lung neoplasms. This case highlights a rare case of aggressive spindle cell carcinoma in a young female patient with no risk factor. Case summary: A 20-year-old female patient with no other comorbidities presented with a chronic cough associated with hemoptysis and right-sided chest pain off and off. Auscultation of the lungs revealed decreased breath sounds over the left lung. X-ray chest and computed tomographic (CT) scan of the chest showed a round homogenous opacity in the left lung. A biopsy of the mass confirmed the diagnosis of spindle cell carcinoma with focal myogenic differentiation and infarctive necrosis. Case discussion: Spindle cell carcinoma is often difficult to diagnose histologically as it usually shows pleomorphism, exhibits minor differentiation, and includes components such as sarcoma, fusiform, or giant cells. Conclusion: Diagnosing spindle cell carcinoma of the lung could be challenging, especially in young patients with no other risk factors.

Source: Annals of Medicine and Surgery

DOI: 10.1097/ms9.0000000000003308