Quantitative susceptibility mapping for Alzheimer’s disease, mild cognitive impairment, and normal aging: evaluation of corpus callosum
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: susceptibility in each part of the CC in AD, mild cognitive impairment (MCI), and healthy control (HC), and assess their associations with neurocognitive scores and QSM value changes in follow-up imaging. Methods: -tests and one-way analysis of variance (ANOVA). Results: Significantly increased susceptibility was observed in the mid-anterior and central parts of the CC for AD patients compared to normal controls (0.051 and 0.103 ppm in AD and -0.014 and 0.003 ppm in HC; P value =0.014 and 0.009). Susceptibility in the mid-anterior, central regions, showed weakly positive correlations with CDR-global scores (r=0.296, P=0.006 and r=0.287, P=0.005). After a 2-year follow-up, susceptibility significantly increased across groups. In the HC group, significant increases were observed in the mid-anterior region (mean difference =0.074 ppm; P value =0.021). For the MCI group, a significant increase in the mid-posterior region (mean difference =0.081 ppm; P value =0.039) was found. For the AD group, a significant increase was found in the mid-posterior and posterior regions (mean difference =0.021 and 0.086 ppm; P value =0.013 and 0.005). Conclusions: The study findings suggest that increased susceptibilities in the mid-anterior and central parts of the CC can serve as a potential biomarker for the diagnosis of MCI and AD and assess cognitive function in these diseases.
DOI: 10.21037/qims-24-319
Institutions: Siriraj Hospital, Mahidol University, Naresuan University
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4409620096