Ultrasound evaluation of changes in endometrial receptivity from the day of ovulation to the day of transfer in patients with a history of intrauterine adhesions: a prospective cohort study
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: High rates of infertility and pregnancy complications in patients with intrauterine adhesion (IUA) even after surgical repair may be associated with poor endometrial receptivity (ER). In our previous study, we found that changes occurred in ER from the day of ovulation to the day of transfer in patients with a normal uterine cavity during natural cycles. However, the changes in ER ultrasound indicators in patients with a history of IUA during natural cycles are unclear, and this study thus aimed to analyze these changes. Methods: A prospective cohort study of 161 women with a history of IUA who underwent frozen-thawed embryo transfer (FET) was conducted. ER changes from ovulation to the transfer day in the overall, clinically pregnant, and nonpregnant populations were analyzed. Patients were further allocated to the mild IUA or moderate-to-severe IUA subgroup based on the degree of IUA. Results: 10.57±2.23 mm, P=0.011) and decreases in other indicators (P<0.05). Conclusions: During natural cycles, in patients with a history of IUA, endometrial morphology mainly changed from type C to B, thickness increased, and the volume and frequency of peristalsis decreased. The blood supply of both the endometrium and subendometrium decreased significantly in the pregnant group. These findings provide a better understanding of the changes in ER in such patients, which is helpful for their pretransfer conversation.
Authors: Yangqin Peng, Mingxiang Zheng, Yuyao Mao, Fei Gong, Yuan Li, Hui Chen, Hengxu Wang, Yan Ouyang, Xihong Li
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4409620149