A new lupane glycoside isolated from Dendrobium officinale with α‐glucosidase inhibitory activity
Year: 2025
Type: article
Abstract: A new lupane triterpene glycoside (1) and four known compounds (2‐5) were isolated from the aerial parts of Dendrobium officinale. Their chemical structures were determined to be 3‐O‐α‐L‐arabinopyranosylbetulinic acid 28‐O‐β‐D‐glucopyranosyl‐(1→6)‐β‐D‐glucopyranosyl ester (1), 3‐O‐α‐L‐arabinopyranosylbetulinic acid 28‐O‐α‐L‐rhamnopyranosyl‐(1→4)‐β‐D‐glucopyranosyl‐(1→6)‐β‐ D‐glucopyranosyl ester (2), 3‐O‐β‐D‐glucopyranosylbetulinic acid 28‐O‐α‐L‐rhamnopyranosyl‐(1→4)‐β‐D‐glucopyranosyl‐(1→6)‐β‐D‐glucopyranosyl ester (3), 6α‐hydroxylup‐20(29)‐en‐3‐on 28‐oic acid (4), and lupeol (5) by analyzing the HR‐ESI‐MS, 1D and 2D NMR spectra including COSY and NOESY. Compounds 1, 2 and 4 showed weak α‐glucosidase inhibitory activity with IC50 values ranging from 87.5 to 98.2 µM.
Source: Vietnam Journal of Chemistry
DOI: 10.1002/vjch.70020
Institution: Vietnam Academy of Science and Technology
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,400
OpenAlex ID: W4409621964