Work

The extracellular matrix protein periostin is required for wound repair in primary human airway epithelia

Year: 2025

Type: article

Abstract: This article highlights the critical role of periostin (POSTN) in airway epithelial and fibroblast-mediated wound repair. Moreover, the study reveals a paracrine signaling loop between airway epithelial basal cells and lung fibroblasts, emphasizing periostin's therapeutic potential for diseases like asthma and idiopathic pulmonary fibrosis.

Source: American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI: 10.1152/ajplung.00039.2025

Authors: Lorena A. Tran, Michael Catlin, Scott Schecter, Andrew L. Thurman, Shreya Ghimire, Rosarie A. Tudas, Brandon Bettis, Ryan M. Gannon, Joseph Zabner, Alejandro A. Pezzulo

Institution: University of Iowa

Language: English

Topic: Connective Tissue Growth Factor Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Environmental Health Sciences

Awards: G2552222957, G2808918844, G4351770427, G5995697272, Environmental Health Sciences Research Center, Iowa Medical Student Summer Research Program in trans-NIDDK Research

OpenAlex ID: W4409624898

FWCI: 0.253

Cites: 24

Cited by: 1

Related to: 10