Work

Atypical Guillain-Barré Syndrome in a Young Adult: Diagnostic Challenges and Lessons Learned

Year: 2025

Type: article

Abstract: Guillain-Barré Syndrome (GBS) is a rare, immune-mediated polyneuropathy that typically presents with ascending weakness, areflexia, and sensory disturbances. This case highlights an atypical presentation of GBS in an 18-year-old female, whose initial symptoms included primarily sensory deficits following routine exercise. The diagnostic process was complicated by unremarkable initial laboratory and imaging findings, but cerebrospinal fluid analysis revealed albuminocytologic dissociation, and electromyography confirmed acute demyelinating polyneuropathy. This case underscores the diagnostic challenges posed by atypical variants of GBS, the importance of thorough neurological evaluation, and the critical role of timely intervention in optimizing outcomes.

Source: Cureus

DOI: 10.7759/cureus.82731

Authors: Hannah Becker, Edena R Khoshaba, David A Ansell

Institution: Rush University Medical Center

Language: English

Topic: Peripheral Neuropathies and Disorders

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4409632292