Sex differences in body mass index and waist circumference trajectories and dementia risk: the HUNT4 70+ study
Year: 2025
Type: article
Study design: Observational Study
Abstract: We examined associations between body mass index (BMI), waist circumference (WC), and dementia risk, and differences in BMI and WC trajectories before dementia diagnosis. We included 9,739 participants (54% women) aged 70+ from the Trøndelag Health Study (HUNT4 70+). BMI was measured four times (1984-2019) and WC three times (1995-2019). Dementia diagnoses were clinically assessed at HUNT4 70+ . Women and men with dementia had higher midlife BMI and WC than those without dementia. These differences diminished closer to diagnosis, especially in women. Midlife obesity in both sexes and midlife overweight, high WC, and overweight/obesity with high WC in men were linked to higher dementia risk. Lower dementia risk was observed with late-life overweight for both sexes, late-life high WC in women, late-life overweight/obesity with normal WC in men or high WC in women. Adiposity measures and their changes influence dementia risk differently in women and men.
Source: GeroScience
Institutions: Oslo University Hospital, Sykehuset i Vestfold, Norwegian National Centre for Ageing and Health, Norwegian Institute of Public Health, Maastricht University, Norwegian University of Science and Technology, Levanger Hospital, Helse Nord-Trøndelag HF, North London NHS Foundation Trust, University College London, Inserm, Université Paris Cité, Equipe de Recherche en Epidémiologie Nutritionnelle, Centre de Recherche Épidémiologie et Statistique, University of Oslo
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $2,890
Funders: Foundation for the National Institutes of Health, Stiftelsen Kristian Gerhard Jebsen, Norges Teknisk-Naturvitenskapelige Universitet, School of Public Health, University of Michigan, Helse Midt-Norge, Sykehuset i Vestfold, Medical School, University of Michigan, Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet, European Research Council, Helse Sør-Øst RHF, Faculty of Medicine and Health, University of Sydney, Norwegian Institute of Public Health
Awards: G1736856933, G5138485313, G7430027226
OpenAlex ID: W4409637161