Work

MeCP2 prevents against sustained ketamine-induced synaptic depression at inhibitory synapses

Year: 2025

Type: article

Abstract: knockout mice. We first observed that BDNF-TrkB signaling is involved in both excitatory and inhibitory responses to ketamine and LM22A-4 treatment via distinct pathways. Moreover, MeCP2 plays a role in stabilizing inhibitory neurotransmission by preventing sustained disinhibition in response to ketamine. Together, this work uncovers the role of MeCP2 function in acute ketamine action and may provide insight toward ketamine-based treatment of RTT.

Source: iScience

DOI: 10.1016/j.isci.2025.112485

Authors: Michelle K. Piazza, Abigael R. Weit, Ege T. Kavalali, Jeffrey L. Neul, Lisa M. Monteggia

Institutions: Vanderbilt University, Vanderbilt University Medical Center

Language: English

Topic: Genetics and Neurodevelopmental Disorders

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240