Work

Transcriptional expression analysis of fosfomycin resistance determinants in Escherichia coli with MDR trait

Year: 2025

Type: article

Abstract: Fosfomycin is a therapeutic alternative for urinary tract infection (UTI). Escherichia coli produces fosfomycin modifying enzymes (fos genes) that is the contributor for resistance to this group of antimicrobials. The current research work characterizes fosfomycin resistance determinants in Escherichia coli and their transferability. Fosfomycin modifying enzyme genes were found to be carried within a plasmid of inc type FIC. Under subinhibitory concentration of fosfomycin, transcriptional expression revealed upregulation for fosA10, fosA8, fosA, and fosA2.The current study emphasizes the necessity of ongoing surveillance of E. coli resistance patterns and transmission dynamics, particularly regards to fosfomycin, to implement the best possible treatment strategy.

Source: Indian Journal of Medical Microbiology

DOI: 10.1016/j.ijmmb.2025.100859

Authors: Jayalaxmi Wangkheimayum, Ng Lakhitombi Chanu, Debadatta Dhar Chanda, Amitabha Bhattacharjee

Institutions: Assam University, Silchar Medical College and Hospital

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,210