FTIR Markers of Prostate Cancer Tissue and Their Correlation With Medical Parameters of Tumor Aggressiveness
Year: 2025
Type: article
Abstract: ABSTRACT Fourier transform infrared spectroscopy (FTIR) was used to investigate chemical differences in prostate tissue caused by prostate cancer and to correlate these data with medical. In FTIR spectra of prostate tissues, a higher amount of peaks originating from phospholipids, amide, and lipid vibrations was detected in comparison with FTIR spectra of control prostate tissues. Principal Component Analysis (PCA) showed that it is possible to differentiate two types of tissues using FTIR range corresponding to (i) phospholipids and amides and (ii) lipids. Machine learning methods showed that values of area under the curve (AUC), accuracy, F1, precision, and recall were higher for the fingerprint range than for the second one. However, values of all these parameters in both analyzed ranges were higher than 0.95. Moreover, the proposed FTIR marker of prostate cancer (wavenumber at 1685 cm−1) correlated with bGleason, pGleason, and ISUP, which suggested that FTIR spectroscopy reflected the medical characterization of prostate cancer.
Source: Journal of Biophotonics
DOI: 10.1002/jbio.70046
Language: English
Subfield: Biophysics
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4409639439