Work

Quartz crystal microbalance experiments reveal structural changes in the Staphylococcus aureus biofilm in the presence of savirin

Year: 2025

Type: article

Abstract: Quartz-crystal microbalance with dissipation (QCM-D) experiments show that green-fluorescent protein labelled Staphylococcus aureus adsorption to a gold QCM electrode is similar for a certain incubation period (here, 6 h) in the presence and absence of the quorum sensing inhibitor, savirin. After this period, cells continue to adsorb in the absence of savirin, but in its presence biofilm formation is severely compromised, with significant changes in the viscoelastic properties of the layer being observed.

Source: Results in Surfaces and Interfaces

DOI: 10.1016/j.rsurfi.2025.100535

Authors: Emilia M. Hudzik, Andrew J. Parnell, Jordan Petkov, Mark Geoghegan

Institutions: University of Sheffield, University of Manchester, Newcastle University

Language: English

Topic: Bacterial biofilms and quorum sensing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $1,190

Funder: Engineering and Physical Sciences Research Council