Work

Inactivation of the Catalytic Activity of Mps1 Kinase Prevents Its Own Degradation at Centrosomes

Year: 2025

Type: article

Abstract: Mps1 kinase plays important roles in regulating centriole assembly, apart from its essential role in spindle assembly checkpoint. Here we report a novel mode of regulating centrosomal Mps1 level, which is governed by its own catalytic activity that promotes its degradation at centrosomes. A kinase-dead mutant of Mps1 or catalytically inactive Mps1 due to treatment with a specific kinase inhibitor is protected from degradation at centrosomes. This autoregulatory mode of controlling Mps1 activity at centrosomes likely restricts excess centriole production in a dividing cell.

Source: Cytoskeleton

DOI: 10.1002/cm.22032

Authors: Shrabani Halder, Arpita Dutta, Rupsa Mondal, Banhi Chowdhury, Benu Brata Das, Shubhra Majumder

Institutions: Presidency University, Indian Association for the Cultivation of Science

Language: English

Topic: Microtubule and mitosis dynamics

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze