Year: 2025
Type: article
Abstract: Photoredox fluoroalkylation has emerged as a powerful method and have unlocked new possibilities in organic chemistry. In this work, the green‐light‐induced copper‐mediated difluoroalkylation of arylsulfonium salts with different XCF2COR reagents is described. The reaction proceeded smoothly at ambient temperature under mild conditions and allowed the formation of a variety of difluoroalkylated arenes in good yields. The photocatalyst, visible‐light, and Cu(I) salt played a synergetic role in the reduction of arylsulfonium salt and XCF2COR to the respective radical intermediates. This metallophotoredox protocol was applicable to the late‐stage difluoroalkylation of multifunctionalized bioactive molecules, offering opportunities to the discovery of new medicinal agents. The transformation showed advantages of mildness, simple operation, good functional group tolerance, a wide range of substrates, and excellent regioselectivity, which provided an interesting alternative to other difluoroalkylation reactions in terms of structural diversity, selectivity, and availability by the application of arylsulfonium platforms.
Source: Chemistry - An Asian Journal
Authors: Fang Xia, Yan‐Hao Wang, Xing‐Yu Ding, Cheng‐Pan Zhang
Institution: Wuhan University of Technology
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
Award: G3712220706
OpenAlex ID: W4409647890