Work

Age-Dependent Risk Factors for Hemorrhagic Events in Moyamoya Disease: The Role of Collateral Vessels

Year: 2025

Type: article

Abstract: OBJECTIVE: To describe profiles of collateral arteries of moyamoya disease (MMD) and analyze risk factors of cerebral hemorrhagic events. METHODS: This study retrospectively analyzed 298 patients diagnosed with MMD at Tiantan Hospital in Beijing, who were divided into pediatric and adult groups. Angiographic features were compared between groups. Angiographic outcomes were assessed between hemispheres with and without cerebral hemorrhagic events in adult and pediatric groups separately. Logistic regression analysis was performed to identify relevant risk factors of cerebral hemorrhage. RESULTS: Among 298 patients, there were 20 hemorrhagic hemispheres in the pediatric group and 106 hemorrhagic hemispheres in the adult group. The superficial temporal artery and middle meningeal artery (MMA) were more prominent in the adult group than in the pediatric group. In the pediatric group, the superficial temporal artery, MMA, posterior choroidal artery, and middle cerebral artery were more prominent in hemorrhagic hemispheres than in ischemic hemispheres. In the adult group, the superficial temporal artery, MMA, and middle cerebral artery were more prominent in hemorrhagic hemispheres than in ischemic hemispheres. Logistic regression analysis showed that presence of the posterior choroidal artery was associated with cerebral hemorrhagic events in pediatric patients with MMD. Disappearance of ophthalmic artery, presence of MMA, and presence of MCA were associated with cerebral hemorrhagic events in adult patients with MMD. CONCLUSIONS: Differences in collateral arteries between adult patients with MMD and pediatric patients with MMD were observed, among which MMA acted as a predictor for cerebral hemorrhage in adult patients with MMD.

Source: World Neurosurgery

DOI: 10.1016/j.wneu.2025.124000

Authors: Rutao Luo, Tong Liu, Wenjie Li, Chenyu Zhu, Huan Zhu, Yan Zhang

Institutions: Capital Medical University, Beijing Children’s Hospital, Beijing Tian Tan Hospital, Beijing Institute for Brain Disorders

Language: English

Topic: Moyamoya disease diagnosis and treatment

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,943