Quantification of Macular and Peripapillary Vascular Density in Myopia Using Optical Coherence Tomography Angiography
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Myopia is a leading cause of correctable visual impairment worldwide, with its prevalence rapidly increasing, particularly in Asia.High myopia (spherical equivalent > -6.00 D) is associated with structural ocular complications that can result in permanent visual loss.Optical coherence tomography angiography (OCTA) allows non-invasive, high-resolution evaluation of retinal and peripapillary vascular changes in myopic eyes.This study aimed to evaluate macular and peripapillary vessel density changes among myopic adults using OCTA and identify associated factors.Methods: A prospective cross-sectional study was conducted from December 2023 to April 2024 involving 60 eyes of myopic adults (18-42 years) at an eye clinic center.Participants were grouped by myopia severity: mild, moderate, and high.OCTA was used to measure vessel density in five macular and peripapillary regions.Statistical analysis included ANOVA and Pearson's correlation.Results: Significant reductions in macular and peripapillary vessel densities were observed in high myopia, particularly in nasal and temporal areas (p<0.0001).Vessel density correlated positively with spherical equivalent and negatively with axial length.Conclusion: Vascular alterations increase with myopia severity.OCTA is a valuable tool in detecting early microvascular changes, emphasizing its role in the monitoring and management of myopic progression.
Institutions: University of Benghazi, University of Ajdabiya
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4409650893