Work

Chemical Synthesis of Two Fucosylated Human Milk Oligosaccharides: 3‐Fucosyllactose and Lacto‐N‐fucopentaose V

Year: 2025

Type: article

Abstract: Glycans present in human milk have been the focus of many studies due to challenges associated with their synthesis. The development of new methods for obtaining individual glycans found in human milk has been a vibrant area of research in glycosciences. This study reports the synthesis of two fucosylated glycans found in human milk, 3-fucosyllactose, which was previously synthesized by both chemical and enzymatic methods, and the first chemical synthesis of lacto-N-fucopentaose V. Screening different protecting and leaving groups, as well as optimizing the glycosylation reaction conditions helped us to achieve efficient assembly and deprotection of these two fucosylated human milk oligosaccharides in good yields.

Source: Chemistry - A European Journal

DOI: 10.1002/chem.202500754

Authors: Faranak Pooladian, Anupama Das, Alexei V. Demchenko

Institution: Saint Louis University

Language: English

Topic: Carbohydrate Chemistry and Synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funder: National Institute of General Medical Sciences

Awards: G6426702549, G7690823878