Work

Bioactive Polyurethane Shape Memory Polymer Foam Dressings with Enhanced Blood and Cell Interactions for Improved Wound Healing

Year: 2025

Type: article

Abstract: Polyurethane (PUr) shape memory polymer (SMP) foams have demonstrated excellent bleeding control in traumatic wounds. Unlike the current clinically available treatment options, PUr SMP foams can address noncompressible bleeds, are safe for prolonged use, and are highly tunable, offering broad functionalities like biodegradation and antimicrobial properties. Despite their hemostatic efficacy, PUrs are entirely synthetic, which limits their long-term healing capacity if left in a wound to degrade. This work employed methods for facile incorporation of bioactive collagen and gelatin into PUr foams postfabrication to enhance their clotting efficacy and drive cell interactions. The procoagulant nature of collagen and gelatin increased the clotting accomplished by the PUr SMP foams. Additionally, the bioactive PUr SMP foams promoted cell attachment, spreading, and proliferation on foam pores, which could facilitate tissue migration into the scaffold and promote wound repair. Overall, a bioactive PUr SMP foam dressing could significantly improve traumatic wound healing outcomes.

Source: ACS Applied Materials & Interfaces

DOI: 10.1021/acsami.5c02532

Authors: Natalie Marie Petryk, Nghia Le Ba Thai, Leo Vikram Saldanha, Shawn Tyrin Sutherland, Mary Beth B. Monroe

Institution: Syracuse University

Language: English

Topic: Wound Healing and Treatments

Subfield: Rehabilitation

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500