Work

Mechanistic insights into Hippo-YAP pathway activation for enhanced DFU healing

Year: 2025

Type: article

Abstract: This study provides unprecedented insights into diabetic foot ulcer healing by demonstrating the novel immunoregulatory role of the TFAP2A-LIFR-Hippo-YAP signaling axis. Leveraging single-cell and bulk transcriptomics, we identify TFAP2A as a crucial regulator of macrophage M2 polarization, essential for wound healing and angiogenesis. These findings offer valuable mechanistic understanding and present TFAP2A as a promising therapeutic target for improving outcomes in chronic diabetic wounds.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.01067.2024

Authors: Shaochun Zhang, Ye Wang, Xuesong Xiong, Jili Xing, Ke Jing

Institution: Ezhou Central Hospital

Language: English

Topic: Wound Healing and Treatments

Subfield: Rehabilitation

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Natural Science Foundation of Hubei Province, Science and Technology Department of Hubei Province