Work

Visible/Red/NIR Light-Mediated NO Donors for Biological Applications

Year: 2025

Type: article

Abstract: Nitric oxide (NO) is an important messenger molecule in almost all organisms. The diverse biological activities of NO have initiated in-depth research on the development of exogenous NO donors. Light-controlled NO donor can transport NO to specific areas to treat various diseases; thus, light–triggered NO donors are rapidly becoming an important class of compounds for the design of novel potential drugs. This review highlights the recent development of organic small molecule-based light-triggered NO donors and focuses on visible/red/NIR light-mediated NO donors. It contains rational designs of NO donor, NO releasing mechanism and detection, as well as its biological applications. Finally, the advantages, drawbacks, and challenges of this strategy are discussed in view of practical applications.

Source: Chemistry

DOI: 10.3390/chemistry7030066

Author: Yi Chen

Institutions: Chinese Academy of Sciences, Technical Institute of Physics and Chemistry, University of Chinese Academy of Sciences

Language: English

Topic: Molecular Sensors and Ion Detection

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,172