EXPRESSION OF CONCERN: Novel proline endopeptidase inhibitors do not modify Aβ40/42 formation and degradation by human cells expressing wild‐type and Swedish mutated β‐amyloid precursor protein
Year: 2025
Type: article
Abstract: EXPRESSION OF CONCERN: A. Petit, H. Barelli, P. Morain, F. Checler, “ Novel proline endopeptidase inhibitors do not modify Aβ40/42 formation and degradation by human cells expressing wild-type and Swedish mutated β-amyloid precursor protein,” British Journal of Pharmacology 130, no. 7 (2000): 1613–1617, https://doi.org/10.1038/sj.bjp.0703440 This Expression of Concern is for the above article, published online on 29 January 2009 in Wiley Online Library (wileyonlinelibrary.com), and has been issued by agreement between the journal Editor-in-Chief, Péter Ferdinandy; the British Pharmacological Society; and John Wiley & Sons Ltd. A third party reported to the journal that the Aβ 40 (Aβ 42) panel in Figure 4A had been duplicated in Figure 5A and that the last two gel panels of βAPP in Figure 4B appear to have been duplicated in Figure 5B. An investigation by the publisher and journal confirmed this report and that both sets of data are presented as having different experimental conditions. The authors responded to an inquiry by the publisher and stated that the βAPP images are the same, but that these cells were treated with two different inhibitors in Figures 4B and 5B and that each had different Aβ 42 expressions. The authors stated that the original data are not available due to the considerable time since publication. This Expression of Concern has been agreed to because the data included in this article cannot be validated. Therefore, the journal has decided to issue an Expression of Concern to inform and alert the readers. Author F. Checler disagrees with the Expression of Concern. Authors A. Petit, H. Barelli, and P. Morain did not respond to our notice regarding the Expression of Concern.
Source: British Journal of Pharmacology
DOI: 10.1111/bph.70068
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4409669880