Work

Extending dynamic and operational range of the biosensor responding to l-carnitine by directed evolution

Year: 2025

Type: article

Abstract: mM-10 mM, was obtained. The response range was 1000-fold wider and the output signal intensity was 3.3-fold higher to that of the control biosensor. These variants may have great value in improving the l-carnitine production process.

Source: Synthetic and Systems Biotechnology

DOI: 10.1016/j.synbio.2025.04.012

Authors: Tingting Li, Huina Dong, Jinlong Li, Huiying Wang, Chunxiang Pu, Siyu Chen, Zhiying Yang, Xinyi Ren, Xuan Liu, Zhaoxia Jin, Dawei Zhang

Institutions: Chinese Academy of Sciences, Tianjin Institute of Industrial Biotechnology, Dalian Polytechnic University, University of Chinese Academy of Sciences

Language: English

Topic: Microbial Metabolic Engineering and Bioproduction

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $1,500

Funders: National Natural Science Foundation of China, Chinese Academy of Sciences, National Outstanding Youth Science Fund Project of National Natural Science Foundation of China, National Key Research and Development Program of China, National Science Fund for Distinguished Young Scholars

Awards: G1417105944, G1851875827, G2727311694, G3383687715, G4107300637, G8668955859

OpenAlex ID: W4409670260

FWCI: 0.504

Cites: 45

Cited by: 2

Related to: 10