Work

Reduced composite dietary antioxidant index increases the risk of Parkinson’s disease and all-cause mortality in Parkinson’s disease patients: evidence from the NHANES database

Year: 2025

Type: article

Abstract: Background: This study aimed to investigate the relationship between the Composite Dietary Antioxidant Index (CDAI) and the prevalence of Parkinson's disease (PD), as well as to explore its relationship with all-cause mortality risk in PD patients. Methods: Data from the National Health and Nutrition Examination Survey (NHANES) database spanning from 2007 to 2018 were used, including 119,609 participants. After excluding individuals aged <18 years, those with incomplete follow-up data, and those missing critical variables such as CDAI and covariates, the final cohort consisted of 34,133 participants. Participants were categorized into a PD group (510 individuals) and a non-PD group (33,623 individuals). The CDAI values were calculated, and participants were divided into three groups based on the tertile distribution of their CDAI scores: Q1 (CDAI < -1.07), Q2 (-1.07 to 1.74), and Q3 (CDAI >1.74). Weighted logistic regression and weighted Cox regression analyses were employed to evaluate the associations between CDAI and the prevalence of PD, as well as between CDAI and all-cause mortality risk. Restricted cubic spline regression analysis was used to further elucidate the precise relationship between CDAI and outcome events. Results: = 0.018). This association was particularly pronounced in those over 60 years old, smokers, and those with hypertension. Restricted cubic spline regression analysis identified CDAI <0.471 as a risk factor for PD, and CDAI <0.527 as a risk factor for all-cause mortality in PD patients. Conclusion: CDAI reduction is an independent risk factor for both PD risk in the general population and all-cause mortality in PD patients, with amplified predictive power in older adults, smokers, and hypertensive individuals. Our findings support developing personalized antioxidant-enhancing nutritional interventions for both high-risk populations with suboptimal CDAI and established PD patients.

Source: Frontiers in Aging Neuroscience

DOI: 10.3389/fnagi.2025.1510654

Authors: Fei Huang, Jingwen Hao, Chanjuan Chen, Qun Liu, Dan He

Institution: The First Hospital of Changsha

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801