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A comparative analysis of three graph neural network models for predicting axillary lymph node metastasis in early-stage breast cancer

Year: 2025

Type: article

Abstract: The presence of axillary lymph node metastasis (ALNM) in breast cancer patients is an important factor in deciding whether to have axillary surgery or pursue alternative treatments. Based on axillary ultrasound (US) and histopathologic data, three graph neural network models were compared to predict ALNM in early-stage breast cancer. The patients were randomly divided into two data sets: training (80%) and testing (20%). Predictive performance was measured using accuracy, sensitivity, specificity, positive predictive value, negative predictive value, F1 score, and area under the curve (AUC). In the test cohort, the graph convolutional network (GCN) performed the best in predicting ALNM, with an AUC of 0.77 (95% confidence interval [CI]: 0.69-0.84). In conclusion, the GCN model has the potential to provide a noninvasive tool for detecting ALNM and can aid in clinical decision-making. Prospective studies are expected to provide high-level evidence for clinical usage in future investigations.

Source: Scientific Reports

DOI: 10.1038/s41598-025-97257-z