Consensus Clinical Management Guideline for PLA2G6 -Associated Neurodegeneration (PLAN)
Year: 2025
Type: article
Abstract: associated neurodegeneration (PLAN). PLAN, a neurodegeneration with brain iron accumulation disorder, presents with infantile-onset (infantile neuroaxonal dystrophy), juvenile-onset, and adult-onset forms with motor, cognitive, ophthalmologic, and autonomic symptoms. This guideline was developed using a modified Delphi process with input from PLAN experts and family members of individuals with PLAN. A literature search was performed, although in the absence of data, recommendations were based on expert opinion. The guideline contains recommendations on diagnostic approach, disease-specific treatment, and symptom-based management.
Source: Journal of Child Neurology
Authors: Jenny L. Wilson, Audrey K.S. Soo, Allison Gregory, Nardo Nardocci, Giovanna Zorzi, Matthew Ritzman, Amanda Hope, David W. Duncan, Megan Thomas, Serena Bertoldi, Natale A. Scalise, Patricia Wood, Heather Massey, Amber Denton, Amanda Sargent, Leena Panwala, Penelope Hogarth, Manju A. Kurian, Susan J. Hayflick
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,150
Funder: NBIA Disorders Association
OpenAlex ID: W4409675628