An Efficient Multicomponent, One-Pot Synthesis of Betti Bases Acid Catalyzed at Ambient Temperature
Year: 2025
Type: article
Abstract: The synthesis of aminobenzylnaphthols is achieved through a multicomponent reaction (MCR) involving 2-naphthol, a variety of amines, and aldehydes as starting materials. This one-pot approach is widely utilized in organic synthesis for its ability to efficiently construct complex molecular frameworks in a single step, minimizing the need for purification of intermediates and reducing reaction time. Aminonaphthols, which possess 1,3-aminooxygenated functional groups, are of considerable interest due to their broad biological activity and synthetic versatility. These compounds frequently serve as key intermediates in the synthesis of pharmaceutical agents and bioactive natural products, and are often recognized as pharmacophores in medicinal chemistry. Their unique structural features make them valuable candidates for further derivatization and development in drug discovery.
Author: Sushma Rani
Institution: Patna University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4409675746