Autoimmune Hemolytic Anemia in 62 Year Old Lady with Mixed Connective Tissue Disorder with Subclinical Hypothyroidism: A Rare Presentation
Year: 2024
Type: article
Study design: Case Report
Abstract: Mixed connective tissue disease (MCTD) is an overlap syndrome characterized by the presence of U1RNP antibody with features of polymyositis, scleroderma, and systemic lupus erythematosus. A female 62-year-old patient presented with generalized body weakness since 4 months and shortness of breath for 3 months. The patient had a history of repeated blood transfusions, in view of a clinical history of recurrent blood transfusion with hypothyroidism (anti-TPO positive) with direct coomb test positive with ANA positive. She is a case of autoimmune hemolytic anemia. ANA immunoblot shows U1RNP positive, suggestive of mixed connective tissue disorder. She responded well with prednisolone (1-mg/kg) with a tapering dose.
Authors: Vipin Porwal, Pulkit Jain, Ashish Sharma
Institution: Ruxmaniben Deepchand Gardi Medical College
Language: English
Topic: Blood groups and transfusion
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4409679517