Work

Isolation of Fluconazole-Resistant South Asian Clade Candida auris in Beijing, China

Year: 2025

Type: article

Abstract: Since first isolate of Candida (C.) auris was recognized in 2018 in China, over 60 cases of C. auris colonization or infection have been reported up to 2022, with at least two distinct genetic clade. Most isolates from South Asian clade and South African clade were sensitive and resistant to fluconazole, respectively. Here, we report an isolate of fluconazole-resistant South Asian clade C. auris (PUSH159) from blood. The efflux pump genes MDR1, CDR1, CDR4, SNQ2, and ARB1, and ergosterol biosynthesis gene ERG11 were detected in strain PUSH159. Single nucleotide polymorphism (SNP) analysis revealed that strain PUSH159 carried multiple mutations in drug resistance-associated genes, including a hot-spot mutation (Y132F) in ERG11, missense mutation of E709D in CDR1, and missense mutations of K52N and E464K in SNQ2. Our findings support the genetic diversity and differences in antifungal susceptibility within the South Asian clade, and provide early warning for the emergence of fluconazole-resistant South Asian clade isolates in China.

Source: American Journal of Tropical Medicine and Hygiene

DOI: 10.4269/ajtmh.24-0748

Authors: Linlin Yan, Fan Zhao, Ke Zhang, Pengfei Wang, Shoukui Hu

Institutions: Peking University Shougang Hospital, Zhengzhou University, Zhengzhou Central Hospital

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4409683536

FWCI: 0.709

Cites: 8

Cited by: 1

Related to: 10